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Transcriptomic analyses of laser capture microdissected neurons from postmortem human AD revealed that NFT-containing neurons expressed signaling pathways consistent with cellular senescence, including SCAPs, upreguled pro-survival and inflammatory pathways and downregulated cell death pathways (35)

Lyophilized products can also tolerate room temperature storage for a limited period if they will be used relatively soon

Novel delivery systems may improve stability, but consistent systemic exposure remains a primary challenge

Pyritinol was also able to scavenge oxygen free radicals, thus acting as an antioxidant and improving cerebral circulation [94]

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