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Discussion This is the first systematic review and meta-analysis focused exclusively on RCTs evaluating major cardiovascular events (MACE)

Diabetes Care 41(2):258266

The SUSTAIN-2 trial showed that adding semaglutide to metformin provides significantly better blood sugar control and weight loss compared to other add-on treatments

Also, data analysis showed that the serum GLP-1 level of patients with newly diagnosed T2DM combined with CAS was significantly reduced compared with the control group