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Together, these hierarchical reflex networks maintain efficient propulsion and reservoir functions that need to be strictly regulated to avoid dismotility ( 2.2 Nutrient sensing and neurohormonal regulation of gut motility Meal ingestion is a major physiological trigger of colonic motility, activating the gastrocolic reflex and increasing colonic tone and propagated contractions through integrated neural, hormonal, and bile-acid-dependent mechanisms, with maximal responses typically occurring after breakfast (Tack et al., 2006
Amaro S, Llull L, Ren A, et al
2022 Nov [cited 2025 Mar 21]
P.GomesK
The daily dose is 1.28 mg , drawn as 0.16 mL , injected once a day under the skin of the abdomen
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