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Similarly, WT TDP-43 interacts with several mitochondrial proteins that are crucial for mitophagy and mitochondrial dynamics (Davis et al., 2018)

Figure 10 shows some compounds that showed significant activity in inhibiting XO and URAT1

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Phase 3 results published in December 2025 from the TRIUMPH-4 trial a double-blind, placebo-controlled study in 445 adults with obesity or overweight and knee osteoarthritis showed the 12mg dose producing an average of 28.7% body weight reduction at 68 weeks