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Dulaglutide is a fusion protein consisting of two identical disulfide-linked chains, each composed of a GLP-1 analog (90% homology with native GLP-1) covalently linked to a modified human IgG4 Fc domain [25]

FIGURE 6 Plasma insulin levels sampled from the tail tended to rise from baseline about 60 min after application of semaglutide either i.v

Funding: The present study was partly supported by the Samuel Rahbar Diabetes and Drug Discovery Endowment, Arthur Riggs Diabetes & Metabolism Research Institute and innovation grant from the Wanek Family Project for Type 1 Diabetes at City of Hope

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The cultured SGN explants from WT or gpx1 / mice were treated with peroxynitrite and 10 M BAY 11-7082 for 48 h