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Peer review Peer review information Nature Communications thanks the anonymous, reviewer(s) for their contribution to the peer review of this work

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Studies have shown that administration of an MC1R agonist (PL-8177) significantly reduced the inflammatory response in mice with experimentally-induced autoimmune uveitis [60] and experimentally-induced inflammatory bowel disease in rats [61]

Before starting NAD+ therapy, here are a few important considerations: Avoid use during pregnancy or breastfeeding