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One of the key roles of SCFAs, particularly butyrate, is to maintain the integrity of the gut barrier by regulating mucin gene transcription in the goblet cells, which increases the mucus layer[39]

Percentage calculated using combined data set

Preclinical and clinical data, though predominantly derived from case reports and small cohort studies to date, consistently indicate that GLP-1 RAs - including liraglutide, semaglutide, and the dual GIP/GLP-1 RA tirzepatide - can induce clinically meaningful weight loss, suppress the characteristic severe hyperphagia, and improve key cardiometabolic parameters in both heterozygous and homozygous MC4R variant carriers