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This landmark study remains one of the strongest demonstrations of a neuropeptide's sleep-promoting activity in preclinical models Eur J Neurosci (2007) -- further characterization of cortistatin's sleep neurobiology, confirming the initial findings Anti-inflammatory studies -- cortistatin has demonstrated potent anti-inflammatory effects in multiple preclinical models (IBD: PNAS 2006, sepsis: J Leukoc Biol 2006, arthritis, atherosclerosis)

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Cairo F, Carnevale G, Nieri M, Mervelt J, Cincinelli S, Martinolli C, et al

Radunz CL, Okuyama CE, Branco-Barreiro FCA, Pereira RMS, Diniz SN