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In the liver, FXR activation dampens DNL by repressing SREBP1 and suppresses the lipogenic genes such as FAS, ACC, stearoyl-Co A desaturase-1

The inclusion of SUCRA-based rankings allowed for a clear and interpretable hierarchy of efficacy across multiple weight loss thresholds

Bupropion's label focuses on seizure risk factors, CYP2D6 substrate interactions, and MAO inhibitor contraindications, but does not single out GLP-1 receptor agonists [2]

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