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Goldberg DM, Spooner RJ

A 2015 meta-analysis found that NAC reduced chronic bronchitis or COPD exacerbations, though later research has been mixed, including a 2024 trial in mild-to-moderate COPD that did not find a significant reduction in overall exacerbation rates with high-dose NAC.1 22 Fertility Oxidative stress can damage sperm, eggs, and the reproductive environment, which is one reason antioxidants are often studied in fertility research

doi: 10.2337/db07-0416 183 HarjutsaloVReunanenATuomilehtoJ

[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Su D., Yang X., Xia Q., Zhang Q., Chai F., Wang C., Qu F

Core molecular mechanisms include the specific oxidative modification of host proteins by HOCl generated via myeloperoxidase catalysis [398], the oxidative activation of NLRP3 inflammasome [399], and HIF-1-mediated gut microbiota dysbiosis [400]