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During the progression of diabetes, hyperglycemia promotes mitochondrial dysfunction and induces the formation of reactive oxygen species (ROS) that cause oxidative stress in several tissues such as blood vessels and pancreatic beta cells ( Figure 1 Gut microbiome dysbiosis is another important factor that can facilitate the induction and progression of metabolic diseases such as T2DM ( Effects of T2DM on the Circulatory System Vascular homeostasis is an important function of the endothelium

10.1007/s13105-024-01039-6 Summary Keywords exercise, atherosclerosis, exerkines, browning of adipose tissue, cell death, microRNAs, immune function Citation Yin M and Guo L (2025) Exercise in atherosclerosis: its beneficial effects and underlying mechanism

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