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The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]

10.1016/j.fbio.2025.107539 156 WengC.GuA.ZhangS.LuL.KeL.GaoP.et al (2023)

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Although clinical, empirical data guides medical practice, every patient is unique and deserves individualized considerations, he says

CHIVAA prospective study of a vein sparing technique for the management of varicose vein disease