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Biofilm cells also remodel the components of their plasma membrane lipid composition and cell wall architecture, which contribute to physical and biochemical changes that reduce drug uptake or increase tolerance to membrane-directed stress ( Metabolic variation in biofilms, including areas of nutrient limitation, oxygen gradients, and slow-growing or metabolically quiescent subpopulations, plays a crucial role in determining the efficacy of drugs

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Back Kreymann, B, Ghatei, MA, Williams, G, Bloom, SR (5 Dec 1987), The Lancet , 330/8571, 1300-04

Binding most strongly to MC1R, the receptor expressed on melanocytes in the basal layer of the epidermis