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5 Evidence and controversies regarding the GFD in the management of HT-CD comorbidity 5.1 Established value in CD and possible benefit in CD-HT comorbidity For CD, the evidence is clear: a strict lifelong GFD remains the cornerstone of therapy, improves symptoms, lowers serologic activity, and supports mucosal recovery

The BM of the BBB is a multilayered extracellular matrix composed of laminin, collagen IV, nidogen, and proteoglycan, formed by the interplay between astrocytes, BECs, and pericytes (66, 73)

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By combining two peptides known for their regenerative properties, this approach offers a deeper path toward healingone that aims not just for short-term relief, but for long-term resilience and optimal recovery