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Published studies have documented pigmentation responses across a range of baseline skin types and UV exposure conditions

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Additional at-risk groups include: Vegans and strict vegetarians , who may have low dietary B12 intake People with autoimmune conditions , including pernicious anaemia or type 1 diabetes Individuals with gastrointestinal conditions such as Crohn's disease or coeliac disease, which impair nutrient absorption People who have undergone bariatric surgery , which can significantly reduce B12 absorption Long-term users of proton pump inhibitors (PPIs) or H2-receptor antagonists , which reduce gastric acid and impair B12 release from food Those with a family history of either pernicious anaemia or diabetes For these groups, simultaneous monitoring of B12 status and glycaemic markers is particularly important to avoid diagnostic errors

Logan, M.D., with a doctorate in medicine and a degree in molecular biology

Protein expression and purification Expression and purification of TRF1 TRFH domains was carried out as described previously with some modifications 15,31