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Clinical Evidence In a 2021 clinical trial (SURPASS-2), tirzepatide was found to have greater reductions in hemoglobin A1c (HbA1c) and body weight than semaglutide 1 mg in people with type 2 diabetes [6]

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doi: 10.1016/J.JFCA.2024.107146 60 De CleeneM.De LeyJ

The more clinically relevant question is whether controlled glucagon receptor activation, when paired with GLP-1 and/or GIP receptor agonism, can shift glucagons metabolic impact from primarily hyperglycemic toward thermogenic, lipolytic, and hepatometabolic benefit