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This cell death is associated with apoptosis-like morphological signs, including cell shrinkage, membrane blebbing, and phosphatidylserine externalization

Going beyond this introduces increasing uncertainty about both potency and sterility

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Dominant negative Gs (DNGs) includes mutations S54N, G226A, E268A, N271K, K274D, R280K, T284D, I285T and A366S of Gs, which has been described preciously to reduce nucleotide binding affinities and enhance the stability of GLP-1R and Gs heterotrimer complex(Liang, Belousoff, Fletcher, et al