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The dosing framework comes from extrapolation: murine studies scaled by body surface area, in vitro keratinocyte studies reverse-engineered to estimate required serum concentration, and anecdotal protocols from research communities using off-label peptides

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Transmission electron microscopy (TEM) scanning revealed no significant difference between LNPs and CD5-modified LNP (CD5/ LNP), both of which had bilayer membranes of ~4 nm and core regions with dense nucleotides (Fig

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