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Weight Loss: The Default Job The pivotal obesity trial enrolled about 1,960 non-diabetic adults with a mean weight of 105 kg, BMI of 38, average age of 46, and a cohort that was roughly three-quarters women

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41 Also of note, occludin-null mice were born in expected Mendelian ratios with no gross phenotype, although they did show significant postnatal growth retardation

Future studies should evaluate the efficacy of the natural products in female mice to gain a more comprehensive understanding of their therapeutic potential across both sexes