2023 Aug;25(4):454-471
You are a fusion of so many things - juggling everything life throws at you, every day
Drug families known to disrupt HPG axis signaling and/or decrease fertility by other mechanisms include 23 : Chemotherapy drugs (such as cisplatin, doxorubicin (Adriamycin, among others), 5-fluorouricil (5-FU), cyclophosphamide) 52 Psychiatric medications 23 Corticosteroids and other immune suppressants 23,69 Some blood pressure-lowering drugs including calcium channel blockers, angiotensin receptor blockers (ARBs), and angiotensin-converting enzyme inhibitors (ACEi)
Serious side effects are rare but require medical attention
The greater decrease in LAC levels in severe forms of MDD and in patients with treatment resistant depression (TRD) is akin to a kindling-like progression of depression in that earlier age at onset and/or the presence of early life adversity, such as emotional trauma, conveys liability to more severe and treatment-resistant course of illness [51, 53, 55]