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Secreted from enteroendocrine cells of the upper (GIP) or lower (GLP-1) intestine in response to food intake, they not only stimulate pancreatic insulin secretion in a glucose-dependent manner but also act in the brain to decrease body weight via inhibition of food intake

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Here we describe the synthesis and kinetic characterization of a fluoromethyl-M(5) analogue that acts as a mechanism-based inhibitor of both enzymes

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