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Defining the correlation between immune-checkpoint inhibitors-related adverse events and clinical outcomes: a narrative review Omar Abdihamid 1 , Abeid Omar 2 and Tibera Rugambwa 3 1 Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, Peoples Republic of China 2 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Champlion Street, Alazarita, Alexandria 21131, Egypt 3 Department of Internal Medicine, Mbeya Zonal Referral Hospital, Mbeya 419, Tanzania Abstract Immune checkpoint inhibitors (ICIs) have increased modern anticancer armamentarium portfolios, with 15%60% of cancer patients deriving clinical benefit while others progress, including some occurrences of accelerated progressions