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However, their high cytotoxicity possibly compromising epithelial integrity greatly limited their clinical translation

The COA availability and batch information were appreciated

NAD+ (not a peptide) is usually given by IV because oral NAD+ is poorly absorbed

The results showed that overexpression of -Syn and the formation of oligomers have cytotoxic effects, upregulate local inflammatory markers, induce LC fiber degeneration, disrupt striatal dopamine metabolism, and exacerbate non-motor behaviors in PD

It should be noted that changes in other lipid species that are relevant to liver injury and inflammation, such as acyl-CoAs, diacylglycerides, ceramides and sphingolipids 42 , were not investigated in the present study