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Can combine : Yes, many use both (apply at different times) GHK-Cu vs Botox/fillers Botox/Fillers : Immediate results Requires professional administration $300-1,000+ per treatment Lasts 3-6 months Doesn't improve skin quality GHK-Cu : Gradual natural improvement Self-administered (injectable) or topical $30-60 per month Long-lasting with continued use Actually improves skin structure Winner : GHK-Cu for natural, long-term results

Both decline with age, and some research suggests combined support may offer complementary effects on mitochondrial function and oxidative stress

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Exendin-4 reduces S-phase kinase associated protein 2 expression and upregulates p27Kip1 in a dose-dependent manner, inducing G0/G1 phase arrest in ALVA-41 cells and thereby suppressing proliferation (145)

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