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The directional migration is mediated by secreted chemokines that form a concentration gradient towards the site of inflammation (Koopmann and Krangel, 1997)
Nonetheless, use of HU therapy in SCD has expanded substantially in recent years
Provincial coverage Public coverage criteria vary by province and often require prior use of first-line therapy such as metformin before Ozempic for type 2 diabetes is covered
A 2024 pharmaceutical review in Pharmaceuticals raised tumorigenesis as a theoretical risk, though a 2025 response published in the same journal directly countered the concerns
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