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This process promotes the oligomerization of p62 with Keap1, facilitating the degradation of Keap1 and the subsequent nuclear translocation of Nrf2 via cellular autophagy

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Nat Neurosci 9:917924 Lewis CA, Solomon JN, Rossi FM et al (2009) Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1

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Microglial ablation during the symptomatic phase of EAE has been shown to reduce CNS inflammation and promote recovery (Nissen et al., 2018), but impeding microglial function may also limit remyelination (Stangel et al., 2017