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Microdosing falls entirely outside MHRA and NICE guidance, and off-label use is not routinely NHS-funded

doi: 10.1200/JOP.777003 205 CaoMDLamichhaneSLundgrenSBofinAFjosneHGiskeodegardGFet al

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The relevance for autoimmune patients includes potential effects on bone density (important for patients on corticosteroids or with conditions like lupus that increase osteoporosis risk) and additional anti-inflammatory pathways that GLP-1-only drugs do not activate

This has prompted growing investigation into the use of GLP-1 receptor agonists in the treatment of substance use disorders, including alcohol, nicotine, stimulant, and opioid dependence