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Both chemokines attract activated immune cells to the islets (48, 49), and CXCL10 has been shown to exert direct toxicity on the -cells (50)

RNA samples were treated with the TURBO DNA-free kit (Applied Biosystems, Foster City, CA), further purified through an RNease kit (Qiagen) and quantified with a NanoDrop-1000 (NanoDrop Technologies Inc., Wilmington, DE)