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We observed that the IC50 values of glioblastoma cell lines were lower than those of HEB ( Fig
1517 The low ambient concentrations of 4HNE generated during physiological signaling downstream of lipoxygenases act as growth and proliferation signals
Cerebellum 14:8696
Therefore, CGAS/STING may contribute to ferroptosis in depression, given its involvement in multiple CNS disorders, its capacity to induce ferroptosis in various central and peripheral tissues, and importantly, the observation that its inhibition can effectively alleviate depressive-like behaviors
