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Through its metabolites, such as AFMK and 6-OHM, melatonin enhances GSH levels, a key antioxidant, and mitigates UVB-induced GSH depletion 198

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A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients

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If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after dosage increase), consider reducing the dosage (see WARNINGS)