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Results Establishment of CRC Drug-Tolerant Persister Cell Models While modeling the response to the chemotherapeutic drug 5-FU in the CRC cell line HCT116, which has exquisite sensitivity, we observed that the vast majority of the cells were killed within 9 days of exposure to the drug at a concentration 10-fold higher than the IC 50 value ( Figure 1A )

HCG is a heterodimeric glycoprotein composed of an -subunit identical to that of LH, FSH, and TSH and a unique -subunit

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The foundational mechanism work has been complemented by translational-research investigations in disease-model systems and by recent contemporary reviews compiling the broader research framework

Mens Health 37 (2), 166174