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To examine the toxicity and anti-tumour efficacy of DAC and paracetamol, we utilised male NOD/SCID/gamma (NSG) mice (Charles River) in accordance with the UK Home Office Animal (Scientific Procedures) Act 1986 and approved by the local University of Birmingham Ethical Review Committee

Although the researchers replicate a clinical trial finding of a reduction in heart attacks and strokes among patients with existing cardiovascular disease and chronic kidney disease and a reduction in moderate alcohol consumption risk, they find no statistically significant decline in broader emergency department visits or in any major diagnostic category