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Uch-L1 also modulates the turnover of the glutamate receptors NMDAR and AMPAR, and has effects on neurotransmitter release (Cartier et al., 2001
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Binding to HSA causes an increase in hydrodynamic volume, which slows renal clearance 13,14
It isn't overly common, but the risk is greatly increased if you are taking more than one drug that has serotonergic effects The symptoms of serotonin syndrome include: Hyperthermia (increased body temperature) Hypertension (increased blood pressure) Muscle spasms Muscle rigidity Mental status changes (e.g., agitation, delirium, hallucinations, coma) The prescribing information for both phentermine and Adderall warn about serotonin syndrome and recommend not to combine them with other serotonergic agents
