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Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

(3) intervention details, encompassing the type, dosage, and duration of GLP-1 RA use, as well as comparator group specifications

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Metabolic Very common (10% or more): Hypoglycemia (up to 29.8%), decreased appetite (up to 14%) Common (1% to 10%): Severe hypoglycemia Hypoglycemia (blood glucose less than 54 mg/dL or 3 mmol/L) has commonly been reported in patients with type 2 diabetes

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