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Researchers analysed data from 13 RCTs that investigated the effects of semaglutide and tirzepatide on GI, hepatic, pancreatic, and biliary outcomes

"Behavior is always important but you have to let the pharmacology work." While there is no standard protocol to follow, Ashton said a doctor may try to get a patient to their target, healthy goal weight and then follow the "basic principle of pharmacology" in decreasing the patient to the lowest dose of the medication possible

Choose a convenient time to administer the injection, and keep a consistent schedule

It is typically worst in the first few weeks after starting or increasing a dose and tends to improve significantly as the body adjusts to the medication

Do not blow on the stopper