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The proportion of patients who experienced severe or confirmed ( 8 % at screening Semaglutide versus placebo as an add-on to SGLT2 inhibitor therapy (as monotherapy or in combination with a sulfonylurea derivative or metformin) Therapy with semaglutide at a dose of 1 mg once a week as an add-on to SGLT2 inhibitor therapy (as monotherapy or in combination with a sulfonylurea derivative or metformin) versus placebo once a week for 30 weeks resulted in statistically significant reductions in HbA1c (-1.5 % vs -0.1 %, respectively), FPG (-2.2 mmol/L vs

In the case of the GAL3 parameter, a significant increase of its concentration was observed in the perfrontal cortex of diabetic animals compared to the healthy control group ( F (1,43) = 9.47, P 0.1)