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Other interesting observations come from primary sclerosing cholangitis: specific strains of Klebsiella pneumonia detected in these patients could damage gut barrier integrity, favoring bacterial translocation of other pathobionts toward the mesenteric lymph nodes, and prime a TH17 cell response in the liver, if transplanted into mice models [46]

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Whether the roGFP2 WT (SSG) intermediate is released presumably depends on its size and the geometry of the first and second transition state as outlined below (Fig