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I would reassure the patient that current evidence does not support a strong causal link between GLP-1 receptor agonists like semaglutide and depression or anxiety, says Dr

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their interaction adjusts physiological functions such as behavioral regulation and immune response, and as mentioned before, may have a close interaction with taste cells and their receptors ( 3.1 Alternative nutrient-sensing mechanisms Some nutrients stimulate intestinal hormone secretion independent of taste receptors, via pathways involving other GPCR or nutrient transporters ( Stomach: Calcium-sensing receptor (CaSR) and GPRC6A detect a broad range of amino acids and calcium, promoting gastrin and somatostatin release ( Duodenum: Free fatty acid receptor (FFAR) 1 and CaSR, expressed on I cells, mediate CCK secretion in response to fatty acids and amino acids ( Jejunum and ileum: Sodium-glucose cotransporter 1 (SGLT1) and ATP-sensitive potassium channels (KATP) play critical roles in GLP-1 secretion

Both groups lost weight early, but separation emerged between weeks 48