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Numerous clinical trials have shown that liraglutide can result in significant weight loss among such patients, regardless of whether they have diabetes

Intriguingly, a recent randomised controlled trial found that metformin significantly improved depressive symptoms in patients with treatment-resistant bipolar depression [134]

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It increases intestinal glucose uptake and lactate production, increases GLP-1 concentrations and the bile acid pool within the intestine, and alters the microbiome

Adding glucagon receptor activation to the mix introduces a thermogenic component that neither of those peptides offers