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Obesity inhibited miR-30 expression in adipose tissue macrophages (ATMs), and miR-30 was shown to target Delta-like-4 (DLL4), a Notch1 ligand is associated with ATM inflammation

The percentage of patients who responded to treatment increased from 34% to nearly 39% after one year (Rotaru et al., 2020)

Phenolic Compounds The phenolic compounds of mushrooms which are regarded as aromatic hydroxylated compounds with one or more hydroxyl groups as well as aromatic rings mainly comprise tannins, phenolic acids, oxidized polyphenols, hydroxybenzoic acids, lignans, flavonoids, stilbenes, and hydroxycinnamic acids (DArchivio et al., 2010)

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This involves the selective degradation of anti-ferroptosis proteins or organelles, such as lipid droplets, GPX4, ferritin, SLC40A1, CDH2, and BMAL1 [105, 106, 175,176,177,178,179,180]