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In June, Eli Lilly has announced Phase II results of its SYNERGY-NASH trial in which 54.9% of patients on its dual GLP-1/GIP receptor agonist tirzepatide 5 mg, 51.3% of patients on tirzepatide 10 mg and 51% of patients on tirzepatide 15 mg saw their fibrosis decreaseby at least one stage without their metabolic dysfunction-associated steatohepatitis (MASH) worsening

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Although ICH Q2(R2) is primarily intended for pharmaceutical analytical procedures, its fit-for-purpose validation principles may be used as a non-mandatory scientific reference for research-reagent testing