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The mechanistic principle (GHS release is somatostatin-feedback-governed) is sound and animal data on ipamorelin supports the pulsatile pattern, but ipamorelin-specific pulsatility evidence is limited to animal and in vitro models

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Depression is associated with increased inflammation and given that HPA axis is strictly implicated in inflammation, it is hypothesized that alteration in HPA axis is associated with increase in pro-inflammatory cytokines causing depression, at least with a subgroup of individuals with depression (249)

Both peptides must be reconstituted with bacteriostatic water (not sterile water) and stored at 28C in a refrigerator immediately after mixing