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zer A, et al

[4] Bacterial glutathione transferases are not detected in anaerobic bacteria or archaea

Cell 84 , 335344 (1996)

Doxorubicin (DOX), an antineoplastic drug widely used in anticancer treatment, can increase cardiotoxicity, lead to myocardial injury and heart failure ( Ophiopogon japonicus polysaccharide (OJP) inhibited DOX-induced myocardial ferroptosis through activation of the Nrf2/GPX4 pathway, reduced LDH, CK-MB as well as cTn-I levels, and enhanced ATP generation, hence alleviated myocardial toxicity ( Polygonatum odoratum polysaccharides (POP) activated the Nrf2/HO-1 pathway to inhibit ferroptosis and alleviated cisplatin-induced acute kidney injury ( Aconitum carmichaelii (RFP) had the cytotoxicity effects on hydrogen peroxide-induced injury and prohibited apoptosis in vitro, by contrast, RFP attenuated cisplatin-induced acute kidney injury in vivo through inhibition of ferroptosis with the increased levels of GSH and GPX4, the decreased levels of MDA and 4-hydroxynonenal as well as the reduced lipid peroxidation ( 5 Conclusion and prospects More and more attentions are attracted by plant polysaccharides due to their diverse biological effects including anticancer activity, enhancement of immune responses, antioxidation and stimulation of endogenous factor release

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