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Comparison of the exendin-4 and exendin-P5 bound (PDB 6B3J) structures revealed similarities in their ECD location and greater similarities of the backbone orientations for TMs 1-5, relative to the GLP-1- and oxyntomodulin-bound complexes (Figure 3)

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Hydration Support elimination/excretion via the kidney Sweating (movement, saunas, etc.) Support elimination/excretion via dermal routes Optimize Nutrition Focus on a whole foods diet to maximize fiber and nutrient density Judicious Use of Supplements and/or Pharmaceuticals Personalization of the therapeutic journey is key as each patients presentation and history is unique