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Many insurance plans require prior authorization, step therapy (which involves trying other medications first), or documentation of medical necessity before approval

This mechanism explains the core logic of its weight loss effect - by reducing energy intake, forcing the body to use fat reserves for energy supply

The peptides effects are independent of pituitary function and growth hormone control, allowing for more precise study of IGF-1 receptor-mediated effects

Semaglutide is available in both injectable and oral forms