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Among the compounds that the enzyme reduces there are phospholipids, fatty acids and DNA hydroperoxides produced by lipid peroxidation and oxidative damage to DNA 1

GLUTATHIONE A potent antioxidant that helps target photoaging, oxidative stress, and reduces the concerns associated with exposure to free radicals

As a -glutamyl cyclotransferase, CHAC1 degrades glutathione, affecting calcium signaling and mitochondrial function

The decrease in SF3B1 phosphorylation observed after longer inhibition ( 1 h) can be attributed to roles of these kinases in transcription, a process upstream of splicing 8,20,72 , and, in the case of CDK7 to its recently described role in CDK11 activation 75,82,83

Why is glutathione handled as a drug, not a cosmetic