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Finally, it is not clear to what extent immersive treatment (see Supplementary material 1) and additional interventions during KMT, such as close digital monitoring, frequent clinical contact, group supports, and nature walks, contributed to the rapidity of response/remission of anxiety and depression, or to overall treatment success, independent of the biological effects of KMT, and which of these elements were most critical

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The mechanism: STAT5 phosphorylation peaks within 30 minutes of GH binding, then dephosphorylates over 90120 minutes

PMID 31900483