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FDA-approved weight management medications beyond GLP-1 agonists include: Phentermine-topiramate (Qsymia): Combination sympathomimetic and anticonvulsant showing 8-10% weight loss in clinical trials

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The guidance goes on to say medicines in this category should not be prescribed unless the pharmacy has been assured that the prescriber has contacted the GP in advance of issuing a prescription, and that the GP has confirmed to the prescriber that the prescription is appropriate for the patient and that appropriate monitoring is in place

Gastrointestinal symptoms

Lower doses are typically more affordable, but they are only used for a short adjustment period