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A study from China found that fruits and vegetables helped to lower homocysteine in most MTHFR genotypes, while soy raised homocysteine in females with CC and CT genotypes

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[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered

Beyond weight reduction, researchers documented improvements in BMI, waist circumference, fasting plasma glucose, HbA1c, blood pressure, and liver fat content

The design strategy and mechanism were outlined in Fig