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These transgenic mice showed significantly reduced plasma testosterone levels (18% of normal)[124] and the IGF-I deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, with fewer and smaller Leydig cells than normal

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Their study found that 44.7% of ME/CFS patients had elevated blood lactate at rest which was correlated with increased severity of PEM, although this study did not see a correlation with fatigue severity (Ghali et al., 2019)

& Kemp, M

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